Birth measurements, family history, and environmental factors associated with later-life hypertensive status
Open Access
- 1 April 2012
- journal article
- Published by Oxford University Press (OUP) in American Journal of Hypertension
- Vol. 25 (4), 464-471
- https://doi.org/10.1038/ajh.2011.262
Abstract
This birth cohort study was conducted to investigate the contribution of prenatal and antenatal environmental exposures to later-life hypertensive status. Two thousand five hundred and three individuals born in 1921–1954 at the Peking Union Medical College Hospital (PUMCH) were targeted; 2,081 (83.1%) participated. Clinical examinations included an interview, blood pressure (BP) measurements, and laboratory assays. Statistical analyses were performed using ordinal regression models with later-life hypertensive status as the dependent variable. Similar analyses were for subpopulations divided by family history of hypertension. In the 2,081 subjects, 449 were normotensive, 531 were prehypertensive, and 1,101 had hypertension. Three hundred and forty two hypertensive patients were classified as high-risk (BP ≥180/110 mm Hg, or accompanied with diabetes or three well-established cardiovascular risk factors); the other 759 patients were at mid-to-low risks. Lower birth weight (P = 0.02; 2,500– P < 0.01; 3,000– P = 0.01), family history of hypertension (OR = 1.73, P < 0.01), poor education (OR = 1.76, P < 0.01), and alcoholism (OR = 3.05, P < 0.01) significantly predicted later-life high-risk hypertension. For participants with hypertensive family history (57.7%), the association with birth weight became nonsignificant, but poor education (OR = 2.33, P < 0.01) and alcoholism (OR = 3.10, P = 0.01) remained important. For participants without hypertensive family history (42.3%), the effects of lower birth weight (P = 0.02; 2,500– P = 0.01; 3,000– P = 0.01) and alcoholism (OR = 3.23, P < 0.01) remained significant. Low birth weight, low education, alcoholism, and hypertensive family history are linked to later-life hypertensive status. Low birth weight is also partly associated with one's genetic background; whereas the association with education and alcoholism are independent from hypertensive family history.Keywords
This publication has 21 references indexed in Scilit:
- Lifespan influences on mid- to late-life cognitive function in a Chinese birth cohortNeurology, 2009
- Evidence of a Relationship Between Infant Birth Weight and Later Diabetes and Impaired Glucose Regulation in a Chinese PopulationDiabetes Care, 2008
- The Association of Low Birth Weight and Physiological Risk Factors of Hypertension in African American AdolescentsJournal of Cardiovascular Nursing, 2007
- Significant paternal contribution to the risk of small for gestational ageBJOG: An International Journal of Obstetrics and Gynaecology, 2005
- Low Birth Weight Is Associated With Increased Sympathetic ActivityCirculation, 2003
- Geographic variations in the prevalence, awareness, treatment and control of hypertension in ChinaJournal Of Hypertension, 2003
- Evidence for Genetic Factors Explaining the Birth Weight–Blood Pressure RelationHypertension, 2000
- The role of size at birth and postnatal catch-up growth in determining systolic blood pressureJournal Of Hypertension, 2000
- Fetal origins of coronary heart diseaseBMJ, 1995
- Human blood pressure determination by sphygmomanometry.Circulation, 1993