A region of the 75 kDa neurotrophin receptor homologous to the death domains of TNFR‐I and Fas
- 30 October 1995
- journal article
- Published by Wiley in FEBS Letters
- Vol. 374 (2), 216-220
- https://doi.org/10.1016/0014-5793(95)01113-s
Abstract
Members of the NTR/TNFR family mediate apoptosis in many tissues, yet sequence homology has not been detected in their intracellular domains except for a ‘death domain’ in TNFR-I and Fas. Here, a region of the 75 kDa neurotrophin receptor (NTR) has been aligned with this apoptosis-inducing motif. Peptides at the carboxyl terminus of each domain potentially form amphiphilic helices, one of which (in NTR) resembles mastoparan, a G-protein activating peptide. Molecular models of three death-region peptides suggest that observed sequence similarities reflect a common structure, perhaps capable of undergoing an induced coil to helix transition.Keywords
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