Value of the Unenhanced Phase for Detection of Hepatocellular Carcinomas 3 cm or Less When Performing Multiphase Computed Tomography in Patients With Cirrhosis
- 1 January 2007
- journal article
- abdominal imaging
- Published by Ovid Technologies (Wolters Kluwer Health) in Journal of Computer Assisted Tomography
- Vol. 31 (1), 86-92
- https://doi.org/10.1097/01.rct.0000233126.21303.f0
Abstract
Objective: To determine whether unenhanced images are of added benefit to dual-phase computed tomography (CT) for detection of hepatocellular carcinomas (HCCs) 3 cm or less. Methods: Thirty-six patients with cirrhosis underwent unenhanced, arterial and portal venous phase CT, 17 with pathologically proven HCCs 3 cm or less and 19 without HCC. Two radiologists reviewed dual-phase images with and without unenhanced images. Presence or absence of HCC in each segment (n = 324) and subjective added benefit of unenhanced images were recorded. Results: For readers 1 and 2, unenhanced CT was subjectively helpful in 16 (5%) of 324 and 23 (7%) of 324 segments. Sensitivity and area under the receiver operating characteristic curve were identical for dual-phase versus triple-phase images for reader 1 (82.4% and 0.882) and reader 2 (100% and 0.997). Conclusions: Addition of unenhanced to dual-phase CT does not statistically significantly increase the diagnostic accuracy or sensitivity for HCCs 3 cm or less.Keywords
This publication has 25 references indexed in Scilit:
- Pretransplantation Diagnosis and Staging of Hepatocellular Carcinoma in Patients with Cirrhosis: Value of Dual-Phase Helical CTAmerican Journal of Roentgenology, 2004
- Hepatocellular carcinoma in advanced liver cirrhosis: CT detection in transplant patientsAbdominal Radiology, 2004
- From the RSNA Refresher CoursesRadioGraphics, 2001
- Hepatocellular carcinoma: global epidemiology.Digestive and Liver Disease, 2001
- Pretransplantation Surveillance for Possible Hepatocellular Carcinoma in Patients with Cirrhosis: Epidemiology and CT-based Tumor Detection Rate in 430 Cases with Surgical Pathologic CorrelationRadiology, 2000
- Detection of Hepatocellular Carcinomas and Dysplastic Nodules in Cirrhotic LiversAmerican Journal of Roentgenology, 2000
- Rising Incidence of Hepatocellular Carcinoma in the United StatesNew England Journal of Medicine, 1999
- Mosaic Pattern of Hepatocellular Carcinoma: Histologic Basis for a Characteristic CT AppearanceJournal of Computer Assisted Tomography, 1996
- Malignancies in patients with cirrhosis: CT sensitivity and specificity in 200 consecutive transplant patients.Radiology, 1994
- RISK FACTORS IN DEVELOPMENT OF HEPATOCELLULAR CARCINOMA IN CIRRHOSIS: PROSPECTIVE STUDY OF 613 PATIENTSThe Lancet, 1985