Possible involvement of T helper type 2 responses to Toll-like receptor ligands in IgG4-related sclerosing disease
- 23 March 2010
- Vol. 59 (4), 542-545
- https://doi.org/10.1136/gut.2009.200972
Abstract
We report a case of immunoglobulin G4 (IgG4)-related sclerosing disease involving the pancreas, liver and salivary glands. Massive infiltration of IgG4-expressing plasma cells was seen in the liver and submandibular lymph nodes. Interestingly, accumulation of IgG4-expressing plasma cells was also seen in the colon and terminal ileum. Peripheral blood mononuclear cells (PBMCs) isolated from this patient exhibited enhanced production of IgG4 and interleukin-10 upon stimulation with Toll-like receptor (TLR) ligands as compared with those from a healthy control. In contrast, production of tumour necrosis factor α and interferon γ by PBMCs from this patient was markedly reduced. Since colonic mucosa is always exposed to TLR ligands derived from commensal organisms, the results of immunological studies suggest that enhanced T helper type 2 responses to intestinal microflora may underlie the immunopathogenesis in this patient with IgG4-related sclerosing disease.Keywords
This publication has 14 references indexed in Scilit:
- IgG4-related autoimmune pancreatitis involving the colonic mucosaEuropean Journal of Gastroenterology & Hepatology, 2008
- Circulating Naïve and CD4+CD25high Regulatory T Cells in Patients With Autoimmune PancreatitisPancreas, 2008
- A Novel Immunoglobulin-Immunoglobulin Interaction in AutoimmunityPLOS ONE, 2008
- Muramyl dipeptide activation of nucleotide-binding oligomerization domain 2 protects mice from experimental colitisJCI Insight, 2008
- Th2 and regulatory immune reactions are increased in immunoglobin G4-related sclerosing pancreatitis and cholangitisHepatology, 2007
- The fundamental basis of inflammatory bowel diseaseJCI Insight, 2007
- Common and unique mechanisms regulate fibrosis in various fibroproliferative diseasesJCI Insight, 2007
- Autoimmune PancreatitisThe New England Journal of Medicine, 2006
- Autoimmune pancreatitis: proposal of IgG4-related sclerosing diseaseThe Esophagus, 2006
- Gastrointestinal Findings in Patients with Autoimmune PancreatitisEndoscopy, 2005