HIGHER THAN EXPECTED ASSOCIATION OF CLINICAL PROSTATE AND BLADDER CANCERS
- 1 May 2005
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Journal of Urology
- Vol. 173 (5), 1526-1529
- https://doi.org/10.1097/01.ju.0000154700.80042.c6
Abstract
In this study we evaluated the risk of a second malignancy of the bladder or prostate in patients with a previous diagnosis of prostate cancer (PCa) or urothelial cancer (TCC). We retrospectively analyzed all cases of PCa and TCC diagnosed between January 1996 and June 2003. Only PCa diagnosed due to abnormal digital rectal examination or increased prostate specific antigen were included. All patients with TCC presented with hematuria or irritative voiding symptoms and the diagnoses were confirmed with a tissue diagnosis. The incidence of lung, colon and renal cancers was also analyzed. A total of 816 men were diagnosed with PCa and/or TCC. Of 673 men initially diagnosed with PCa 21 had TCC. Of 149 men initially diagnosed with TCC 18 had PCa. Average age at PCa and TCC diagnosis ± SD was 68.2 ± 7.9 and 68.2 ± 10.4 years, respectively. The standardized incidence ratio (SIR) of TCC in patients with PCa (SIR 4.31, 95% CI 2.411 to 7.110) and of PCa in patients with TCC (SIR 3.83, 95% CI 1.911 to 6.858) was significantly increased. There was no statistical significant difference in SIR for TCC in men with or without radiotherapy. SIR for lung, renal or colon cancer was not significantly different from what was expected. Patients with PCa have higher incidence of bladder cancer and those with bladder cancer have a higher incidence of PCa. This study has clinical implications in the care of these patients and it may stimulate research interest that may identify common pathways of carcinogenesis.Keywords
This publication has 16 references indexed in Scilit:
- Ejaculation Frequency and Subsequent Risk of Prostate CancerJama-Journal Of The American Medical Association, 2004
- Comparative study on the prevalence of clinically detectable prostate cancer in patients with and without bladder cancerUrology, 2004
- Epidemiology of Inflammation and Prostate CancerJournal of Urology, 2004
- Cancer Statistics, 2004CA: A Cancer Journal for Clinicians, 2004
- The Influence of Finasteride on the Development of Prostate CancerNew England Journal of Medicine, 2003
- Second Primary Cancers in Men With Prostate Cancer: An Increased Risk of Male Breast CancerJournal of Urology, 2003
- N-Acetyltransferase expression and DNA binding of N-hydroxyheterocyclic amines in human prostate epitheliumCarcinogenesis: Integrative Cancer Research, 1999
- Epidemiology of prostate cancerCA: A Cancer Journal for Clinicians, 1997
- Coincidence of Bladder and Prostate CancerJournal of Urology, 1997
- Intra-prostatic Urinary Reflux: an Aetiological Factor in Abacterial ProstatitisBritish Journal of Urology, 1982