Phosphorylation of Isocitrate Dehydrogenase of Escherichia coli
- 16 March 1979
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 203 (4385), 1111-1112
- https://doi.org/10.1126/science.34215
Abstract
Addition of acetate to a stationary phase culture of Escherichia coli in glycerol mineral salts medium containing phosphorus-32-labeled orthophosphate results in rapid loss of isocitrate dehydrogenase activity and concomitant incorporation of phosphorus-32 into the enzyme. This is the first example of protein phosphorylation in a bacterium in which the endogenous substrate for the protein kinase has been identified.Keywords
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