A Cinderella Caspase Takes Center Stage
- 23 August 2002
- journal article
- editorial
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 297 (5585), 1290-1291
- https://doi.org/10.1126/science.1076118
Abstract
It has been thought that permeabilization of mitochondria and release of cytochrome c is an ea rly event in apoptosis that is required for activation of caspases, the enzyme executioners of the apoptotic cascade. However, in a Perspective, Kumar and Vaux explain new findings ( Lassus et al.) that implicate an often ignored caspase, caspase-2, in the early stages of apoptosis prior to mitochondrial permeabilization.Keywords
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