Determination of furazolidone in porcine tissue using thermospray liquid chromatography–mass spectrometry and a study of the pharmacokinetics and stability of its residues

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Abstract
A method is presented for the detection of the nitrofuran, furazolidone, in porcine tissue. Following methanol–buffer extraction of the tissue, liquid partitioning, and solid-phase clean-up, samples are analysed by using thermospray LC–MS monitoring the positive ion m/z 243 with filament-assisted ionization. The LOD is 1 µg kg–1. The assay is used to investigate the depletion of furazolidone from tissue and sample stability post mortem. It is necessary to snap-freeze samples by immersion in liquid nitrogen immediately upon collection in order to improve the stability of residues in tissue.