Biosynthesis of Hyperforin in Hypericum perforatum
- 17 September 2002
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 45 (21), 4786-4793
- https://doi.org/10.1021/jm0209782
Abstract
Cut sprouts of Hypericum perforatum were proffered solutions containing [1-13C]glucose or [U-13C6]glucose. Hyperforin was isolated and analyzed by quantitative NMR spectroscopy. The labeling patterns show that the biosynthesis of hyperforin involves five isoprenoid moieties, which are derived entirely or predominantly (>98%) via the deoxyxylulose phosphate pathway. The phloroglucinol moiety is generated via a polyketide type mechanism.Keywords
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