Differentiated Thyroid Carcinoma: The New UICC 6th Edition TNM Classification System in a Retrospective Analysis of 169 Patients
- 1 January 2004
- journal article
- research article
- Published by Mary Ann Liebert Inc in Thyroid®
- Vol. 14 (1), 65-70
- https://doi.org/10.1089/105072504322783867
Abstract
Aim: To compare the new, 6th edition, UICC TNM staging system with the former edition, we updated TNM staging in patients with differentiated thyroid carcinoma. Methods: The new and old TNM classification systems for differentiated thyroid carcinoma were applied in a retrospective analysis of 169 patients who underwent therapy with radioiodine (131I) from 1975 through 2002 at the Department of Nuclear Medicine, Frankfurt. Results: According to the new staging system, 83 patients (49%) were classified as T1 compared to 54 patients (32%) based on the former edition; 32 patients (19%) as T2 compared to 61 (36%) patients formerly. In 44 patients with minimal extrathyroid extension, formerly classified T4, the new TNM staging changed to T3, and no patient was classified T4. The one year relapse-free survival fraction under the former edition staging was 100% for T1 and 92.2% for T2, compared to 96.8% for new edition T1 and 93.3% for T2. Conclusion: The new TNM classification causes a significant change in staging. New T1 classified tumors had a slightly worse relapse-free survival fraction compared with the old T1 carcinomas. For patients treated at our department, the altered criteria for classifying extrathyroid extensions have had only a minor impact on disease management.Keywords
This publication has 7 references indexed in Scilit:
- Positive Predictive Value of Serum Thyroglobulin Levels, Measured during the First Year of Follow-Up after Thyroid Hormone Withdrawal, in Thyroid Cancer PatientsJournal of Clinical Endocrinology & Metabolism, 2003
- Prospective multicenter study of thyroid carcinoma treatmentCancer, 1998
- Microcarcinoma of the thyroid glandCancer, 1998
- A comparison of different staging systems predictability of patient outcomeCancer, 1997
- Papillary microcarcinoma of the thyroid glandBritish Journal of Surgery, 1996
- What do we need beyond TNM?Cancer, 1996
- The clinician and the thyroidEuropean Journal of Nuclear Medicine and Molecular Imaging, 1991