Assessment of Anticholinesterase Activity ofGelidiella acerosa: Implications for Its Therapeutic Potential against Alzheimer’s Disease
Open Access
- 6 December 2012
- journal article
- research article
- Published by Hindawi Limited in Evidence-Based Complementary and Alternative Medicine
- Vol. 2012, 1-8
- https://doi.org/10.1155/2012/497242
Abstract
The effect of various solvent extracts ofGelidiella acerosaon acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activities was investigated. AChE and BuChE inhibitory activities were analyzed by spectrophotometric method. Phytochemical screening of the compounds present in the solvent extracts was done qualitatively. Characterization of the compounds present in the benzene extract ofG. acerosawas done by GC-MS analysis. The results showed that, at 487.80 μg/mL, benzene extract showed significant () inhibitory activity against both AChE and BuChE with the percentage of inhibition% (IC50 = μg/mL) and% (IC50 = μg/mL), respectively. The mode of inhibition exhibited by benzene extract against the AChE and BuChE was found to be competitive and uncompetitive type of inhibition, respectively. Preliminary phytochemical analysis coupled with GC-MS illustrates that the benzene extract possesses high amount of terpenoids, which could be the reason for potential cholinesterase inhibitory activity.
Funding Information
- University Grants Commission (36-6/2008 (SR), BT/BI/25/001/2006)
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