Grading of Gliomas by Using Monoexponential, Biexponential, and Stretched Exponential Diffusion-weighted MR Imaging and Diffusion Kurtosis MR Imaging
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- 1 February 2016
- journal article
- Published by Radiological Society of North America (RSNA) in Radiology
- Vol. 278 (2), 496-504
- https://doi.org/10.1148/radiol.2015142173
Abstract
Our results suggest that advanced diffusion-weighted imaging techniques by using biexponential and stretched exponential models and diffusion kurtosis imaging can provide more valuable information for the grading of gliomas; water molecular diffusion heterogeneity index and mean kurtosis may be more accurate in the grading of gliomas compared with the other diffusion parameters, which would be helpful in improving therapy strategies and prognosis. PurposeTo quantitatively compare the potential of various diffusion parameters obtained from monoexponential, biexponential, and stretched exponential diffusion-weighted imaging models and diffusion kurtosis imaging in the grading of gliomas.Materials and MethodsThis study was approved by the local ethics committee, and written informed consent was obtained from all subjects. Both diffusion-weighted imaging and diffusion kurtosis imaging were performed in 69 patients with pathologically proven gliomas by using a 3-T magnetic resonance (MR) imaging unit. An isotropic apparent diffusion coefficient (ADC), true ADC, pseudo-ADC, and perfusion fraction were calculated from diffusion-weighted images by using a biexponential model. A water molecular diffusion heterogeneity index and distributed diffusion coefficient were calculated from diffusion-weighted images by using a stretched exponential model. Mean diffusivity, fractional anisotropy, and mean kurtosis were calculated from diffusion kurtosis images. All v...Keywords
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