Comparative genomic hybridization analysis of human sarcomas: II. Identification of novel amplicons at 6p and 17p in osteosarcomas
- 1 September 1995
- journal article
- research article
- Published by Wiley in Genes, Chromosomes and Cancer
- Vol. 14 (1), 15-21
- https://doi.org/10.1002/gcc.2870140104
Abstract
Using comparative genomic hybridization (CGH), we have identified and mapped regions of DNA amplification in primary and metastatic osteosarcomas. Samples were obtained from four patients and ten independent xenografts. Sixty-four percent of the tumors showed increased DNA-sequence copy numbers, affecting 23 different chromosomal sites. Most of these regions were not previously associated with the development and/or progression of these tumors. Amplicons originating from 1q21–q23, 6p, 8q23-qter, and 17p11-p12 were observed most frequently. The 6p and 17p11–p12 amplicons seem to be specific for osteosarcomas, indicating that these regions may harbor genes relevant for the development of these tumors.Keywords
This publication has 29 references indexed in Scilit:
- Amplification of chromosome subregion 12p11.2–p12.1 in a metastasis of an I(12p)-negative seminoma: Relationship to tumor progression?Cancer Genetics and Cytogenetics, 1994
- Comparative genomic hybridization as a tool to define two distinct chromosome 12‐derived amplification units in well‐differentiated liposarcomasGenes, Chromosomes and Cancer, 1994
- Cytogenetic study of 249 consecutive patients examined for a bone tumorCancer Genetics and Cytogenetics, 1993
- Comparative Genomic Hybridization for Molecular Cytogenetic Analysis of Solid TumorsScience, 1992
- The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivationCell, 1992
- Report of the Third International Workshop on Human Chromosome 17 Mapping 1992Cytogenetic and Genome Research, 1992
- Oncogenes. The growth control genesArchives of Dermatology, 1991
- Report of the committee on the genetic constitution of chromosome 8Cytogenetic and Genome Research, 1991
- Report of the committee on the genetic constitution of chromosome 15Cytogenetic and Genome Research, 1991
- Report of the committee on the genetic constitution of chromosome 5Cytogenetic and Genome Research, 1991