Association of Serum Vitamin Levels, LDL Susceptibility to Oxidation, and Autoantibodies Against MDA-LDL With Carotid Atherosclerosis
- 1 June 1997
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Arteriosclerosis, Thrombosis, and Vascular Biology
- Vol. 17 (6), 1171-1177
- https://doi.org/10.1161/01.atv.17.6.1171
Abstract
AbstractOxidative modification of LDL is believed to be a crucial step in atherosclerosis. Thus, antioxidant vitamins may have a role in the prevention of coronary disease. We examined the cross-sectional association of serum vitamin levels, the susceptibility of LDL to hemin-induced oxidation (lag phase to conjugated diene formation), and the malondialdehyde-LDL (MDA-LDL) to native LDL radioactivity binding ratio with carotid intima-media thickness (IMT), a measure of asymptomatic early atherosclerosis. The participants in this observational study were 231 asymptomatic age-, sex-, race-, and field center–matched case-control pairs selected from the Atherosclerosis Risk in Communities (ARIC) study cohort on the basis of B-mode carotid artery ultrasonograms obtained from 1986 through 1989. Cases exceeded the 90th percentile of IMT, and control subjects were below the 75th percentile of IMT for all arterial segments. Biochemical analyses were performed on fasting frozen (−70°C) serum specimens collected from 1990 through 1992. In conditional logistic regression adjusting for age, blood storage time, total cholesterol, and log-triglyceride concentrations, serum β-cryptoxanthin and lutein plus zeaxanthin levels were inversely related to the extent of atherosclerosis (odds ratio [OR] per 1-SD increase: 0.75, 95% confidence interval [CI]: 0.59-0.94; and OR per 1-SD increase: 0.76, 95% CI: 0.59-0.95, respectively). Increases in α-carotene and lycopene were associated with nonsignificantly lower odds of being a case, whereas β-carotene, retinol, and α-tocopherol were unrelated to IMT. Although not reaching statistical significance, the lag phase and autoantibodies against MDA-LDL were positively associated with asymptomatic atherosclerosis. After adjustment for potential confounders, only the inverse association of lutein plus zeaxanthin with asymptomatic atherosclerosis was maintained. This study supports a modest inverse association between circulating levels of some carotenoids, particularly lutein plus zeaxanthin, and carotid IMT. These findings suggest that these carotenoid compounds (regarded as biomarkers of fruit and vegetable intake) may be important in early stages of atherosclerosis.Keywords
This publication has 46 references indexed in Scilit:
- Autoantibodies against MDA-LDL in subjects with severe and minor atherosclerosis and healthy population controlsAtherosclerosis, 1996
- High serum alpha-tocopherol, albumin, selenium and cholesterol, and low mortality from coronary heart disease in northern FinlandJournal of Internal Medicine, 1995
- The effect of probucol on femoral atherosclerosis: The Probucol Quantitative Regression Swedish Trial (PQRST)The American Journal of Cardiology, 1994
- Lack of an association between serum vitamin E and myocardial infarction in a population with high vitamin E levelsAtherosclerosis, 1993
- Oxidized LDL and atherogenesis: Relation to risk factors for coronary heart diseaseClinical Cardiology, 1993
- Predisposition to LDL oxidation in patients with and without angiographically established coronary artery diseaseAtherosclerosis, 1993
- Beyond CholesterolNew England Journal of Medicine, 1989
- Role of endothelial cells and their products in the modification of low-density lipoproteinsBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1986
- Serum fatty acids, apolipoproteins, selenium and vitamin antioxidants and the risk of death from coronary artery diseaseThe American Journal of Cardiology, 1985
- Commodity consumption and ischemic heart disease mortality, with special reference to dietary practicesJournal of Chronic Diseases, 1975