An endogenous redox molecule, thioredoxin, regulates transactivation of epidermal growth factor receptor and activation of NF-κB by lysophosphatidic acid

Abstract

Lysophosphatidic acid (LPA) is the smallest and simplest of all the glycerophospholipids that activates a specific GTP-binding protein coupled receptor to evoke multiple cellular responses. In this paper, we have demonstrated that LPA stimulates nuclear factor (NF)-κB-dependent gene induction in a neuronal cell line, NG108-15 and that this is under redox regulation by an endogenous molecule, thioredoxin. We also have shown that redox-sensitive transactivation of epidermal growth factor receptor by LPA confers NF-κB activation and small GTPase proteins are involved in this pathway.