The pathophysiology of hyperuricaemia and its possible relationship to cardiovascular disease, morbidity and mortality
Open Access
- 29 July 2013
- journal article
- review article
- Published by Springer Science and Business Media LLC in BMC Nephrology
- Vol. 14 (1), 164
- https://doi.org/10.1186/1471-2369-14-164
Abstract
Uric acid is the end product of purine metabolism in humans. High levels are causative in gout and urolithiasis. Hyperuricaemia has also been implicated in the pathophysiology of hypertension, chronic kidney disease (CKD), congestive heart failure (CHF), the metabolic syndrome, type 2 diabetes mellitus (T2DM), and atherosclerosis, with or without cardiovascular events. This article briefly reviews uric acid metabolism and summarizes the current literature on hyperuricaemia in cardiovascular disease and related co-morbidities, and emerging treatment options.This publication has 81 references indexed in Scilit:
- Association of kidney disease with prevalent gout in the United States in 1988–1994 and 2007–2010Seminars in Arthritis and Rheumatism, 2013
- Uric acid best predicts metabolically unhealthy obesity with increased cardiovascular risk in youth and adultsObesity, 2013
- Changes in Uric Acid Levels and Allopurinol Use in Chronic Heart Failure: Association With Improved SurvivalJournal of Cardiac Failure, 2012
- 2012 American College of Rheumatology guidelines for management of gout. Part 1: Systematic nonpharmacologic and pharmacologic therapeutic approaches to hyperuricemiaArthritis Care & Research, 2012
- Hyperuricemia predicts adverse outcomes in patients with heart failureInternational Journal of Cardiology, 2011
- Hyperuricemia and Incident Hypertension: A Systematic Review and Meta-AnalysisArthritis Care & Research, 2010
- Hyperuricemia and coronary heart disease: A systematic review and meta‐analysisArthritis Care & Research, 2010
- Hyperuricemia and risk of stroke: A systematic review and meta‐analysisArthritis Care & Research, 2009
- Effect of Allopurinol on Blood Pressure of Adolescents With Newly Diagnosed Essential HypertensionJama-Journal Of The American Medical Association, 2008
- Lowering serum urate does not improve endothelial function in patients with type 2 diabetesDiabetologia, 2007