Phase II Study of High-Dose Lovastatin in Patients with Advanced Gastric Adenocarcinoma
- 1 February 2001
- journal article
- clinical trial
- Published by Springer Science and Business Media LLC in Investigational New Drugs
- Vol. 19 (1), 81-83
- https://doi.org/10.1023/a:1006481423298
Abstract
Lovastatin, an inhibitor of mevalonate synthesis,demonstrated in vitroantitumor activity against avariety of human cancer cells, especially in gastricadenocarcinoma cells at pharmacologically...Keywords
This publication has 9 references indexed in Scilit:
- Phase I study of lovastatin, an inhibitor of the mevalonate pathway, in patients with cancer.1996
- Lipid Metabolism as a Target for Brain Cancer Therapy: Synergistic Activity of Lovastatin and Sodium Phenylacetate Against Human Glioma CellsJournal of Neurochemistry, 1996
- The use of chemotherapy in the treatment of advanced gastric and pancreas cancer.1994
- A phase III randomized study of 5-fluorouracil and cisplatin versus 5-fluorouracil, doxorubicin, and mitomycin C versus 5-fluorouracil alone in the treatment of advanced gastric cancerCancer, 1993
- Synchronization of tumor and normal cells from G1 to multiple cell cycles by lovastatin.1991
- Cell cycle-specific effects of lovastatin.Proceedings of the National Academy of Sciences of the United States of America, 1991
- Lovastatin, a Cholesterol Biosynthesis Inhibitor, Inhibits the Growth of Human H-ras Oncogene Transformed Cells in Nude MiceCancer Communications, 1991
- Inhibition of cell growth by lovastatin is independent of ras function.1991
- Suppression of murine neuroblastoma growth in vivo by mevinolin, a competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.JCI Insight, 1985