Alteration of voltage-dependence of Shaker potassium channel by mutations in the S4 sequence
- 1 January 1991
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 349 (6307), 305-310
- https://doi.org/10.1038/349305a0
Abstract
Voltage-dependent potassium, sodium and calcium ion channels may share a common mechanism of activation, in which the conserved S4 sequence acts as the primary voltage sensor. Site-directed mutagenesis of the S4 sequence of the Shaker potassium channel and electrophysiological analysis suggest that voltage-dependent activation involves the S4 sequence but is not solely due to electrostatic interactions.Keywords
This publication has 38 references indexed in Scilit:
- Voltage-dependent gating of Shaker A-type potassium channels in Drosophila muscle.The Journal of general physiology, 1990
- Sodium channel gating in clonal pituitary cells. The inactivation step is not voltage dependent.The Journal of general physiology, 1989
- Multiple products of the drosophila Shaker gene may contribute to potassium channel diversityNeuron, 1988
- Expression of functional potassium channels from Shaker cDNA in Xenopus oocytesNature, 1988
- Cloning of Genomic and Complementary DNA from Shaker , a Putative Potassium Channel Gene from DrosophilaScience, 1987
- Gating of Na channels. Inactivation modifiers discriminate among models.The Journal of general physiology, 1987
- The structure of the voltage‐sensitive sodium channelFEBS Letters, 1985
- A structural and dynamic molecular model for the sodium channel of ElectrophoruselectricusFEBS Letters, 1985
- Gating currents associated with potassium channel activationNature, 1982
- Kinetics of Channel Gating in Excitable MembranesQuarterly Reviews of Biophysics, 1976