Elevated midline-parietal gamma band noise power in schizophrenia but not in bipolar patients
- 1 February 2016
- journal article
- research article
- Published by Springer Science and Business Media LLC in Archiv Fur Psychiatrie Und Nervenkrankheiten
- Vol. 266 (8), 743-753
- https://doi.org/10.1007/s00406-016-0673-x
Abstract
Gamma oscillations are key in coordinating brain activity and seem to be altered in schizophrenia. In previous work, we studied the spatial distribution of a noise power measure (scalp-recorded electroencephalographic activity unlocked to stimuli) and found higher magnitudes in the gamma band related to symptoms and cognition in schizophrenia. In the current study, we sought to replicate those findings and to study its specificity for schizophrenia in a completely independent sample. A principal component analysis (PCA) was used to determine the factorial structure of gamma noise power acquired with an electroencephalographic recording during an odd-ball P300 paradigm in the 250- to 550-ms window in 70 patients with schizophrenia (16 patients with first episode), 45 bipolar patients and 65 healthy controls. Clinical and cognitive correlates of the resulting factors were also assessed. Three factors arose from the PCA. The first displayed a midline-parietal distribution (roughly corresponding to the default mode network), the second was centro-temporal and the third anterior–frontal. Schizophrenia but not bipolar patients showed higher gamma noise power loadings in the first factor in comparison with controls. Scores for this factor were significantly and directly associated with positive and total symptoms in patients and inversely associated with global cognition in all participants. The results of this study replicate those of our previous publication and suggest an elevated midline-parietal gamma noise power specific to schizophrenia. The gamma noise power measure seems to be a useful tool for studying background oscillatory activity during performance of cognitive tasks.Keywords
Funding Information
- Fondo de Investigaciones Sanitarias (Instituto de Salud Carlos III) (FIS PI080017, FIS PI1102303, FIS PI080514)
- Gerencia Regional de Salud de Castilla y León (GRS 249/A/08, GRS 613/A/11)
- University of Salamanca and Santander Bank (Predoctoral Scholarship)
- Madrid’s Regional Government and the European Union Structural Funds (S2010/BMD-2422 AGES)
- Consejería de Educación-Junta de Castilla y León and European Social Fund
This publication has 50 references indexed in Scilit:
- High-frequency brain activity and muscle artifacts in MEG/EEG: a review and recommendationsFrontiers in Human Neuroscience, 2013
- Gamma synchrony: Towards a translational biomarker for the treatment-resistant symptoms of schizophreniaNeuropharmacology, 2012
- Electroencephalographic Abnormalities in Clozapine-Treated Patients: A Cross-Sectional StudyPsychiatry Investigation, 2011
- Scalp-Recorded Induced Gamma-Band Responses to Auditory Stimulation and Its Correlations with Saccadic Muscle-ActivityBrain Topography, 2010
- Exploring the electrophysiological correlates of the default-mode network with intracerebral EEGFrontiers in Systems Neuroscience, 2010
- Schizophrenia from a neural circuitry perspective: advancing toward rational pharmacological therapiesJCI Insight, 2009
- The Broadband-Transient Induced Gamma-Band Response in Scalp EEG Reflects the Execution of SaccadesBrain Topography, 2009
- The MATRICS Consensus Cognitive Battery, Part 1: Test Selection, Reliability, and ValidityAmerican Journal of Psychiatry, 2008
- EMG contamination of EEG: spectral and topographical characteristicsClinical Neurophysiology, 2003
- A power primer.Psychological Bulletin, 1992