Ultrasound-promoted N-alkylation of imidazole. Catalysis by solid-base, alkali-metal doped carbons
- 14 November 2002
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Green Chemistry
- Vol. 4 (6), 628-630
- https://doi.org/10.1039/b208479c
Abstract
The synthesis of N-substituted imidazoles via alkylation of imidazole with 1-bromobutane by sonochemical and thermally-activated reactions over two alkali-metal promoted carbons (Na+- and Cs+-Norit) as catalysts is reported. In this green, solvent free procedure, N-substituted imidazoles are produced exclusively in very high yields (>80%) when the Cs+-Norit carbon is employed under ultrasound activation. The basicity of the alkali metal cation increases the conversion and ultrasound activation affords a remarkable increase in the yields.Keywords
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