Pseudoephedrine as a Chiral Auxiliary for Asymmetric Michael Reactions: Synthesis of 3-Aryl-δ-lactones
- 1 May 2002
- journal article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 4 (11), 1963-1966
- https://doi.org/10.1021/ol0259847
Abstract
The asymmetric Michael reaction of pseudoephedrine amides is reported. The 1,5-dicarbonyl products are converted to 3-aryl-δ-lactones in a two-step reduction/lactonization sequence. This method provides access to enantiomerically enriched trans-3,4-disubstituted δ-lactones.Keywords
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