Spatial patterns of variation due to natural selection in humans
- 13 October 2009
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Reviews Genetics
- Vol. 10 (11), 745-755
- https://doi.org/10.1038/nrg2632
Abstract
Empowered by technology and sampling efforts designed to facilitate genome-wide association mapping, human geneticists are now studying the geography of genetic variation in unprecedented detail. With high genomic coverage and geographic resolution, these studies are identifying loci with spatial signatures of selection, such as extreme levels of differentiation and correlations with environmental variables. Collectively, patterns at these loci are beginning to provide new insights into the process of human adaptation. Here, we review the challenges of these studies and emerging results, including how human population structure has influenced the response to novel selective pressures.This publication has 108 references indexed in Scilit:
- Winter Temperature and UV Are Tightly Linked to Genetic Changes in the p53 Tumor Suppressor Pathway in Eastern AsiaAmerican Journal of Human Genetics, 2009
- The Population Reference Sample, POPRES: A Resource for Population, Disease, and Pharmacological Genetics ResearchAmerican Journal of Human Genetics, 2008
- Genes mirror geography within EuropeNature, 2008
- Correlation between Genetic and Geographic Structure in EuropeCurrent Biology, 2008
- Independent Introduction of Two Lactase-Persistence Alleles into Human Populations Reflects Different History of Adaptation to Milk CultureAmerican Journal of Human Genetics, 2008
- Genome-wide detection and characterization of positive selection in human populationsNature, 2007
- Diet and the evolution of human amylase gene copy number variationNature Genetics, 2007
- Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDLNature Genetics, 2007
- Convergent adaptation of human lactase persistence in Africa and EuropeNature Genetics, 2006
- Identifying genes underlying skin pigmentation differences among human populationsHuman Genetics, 2006