A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes
- 1 April 1992
- journal article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 356 (6372), 768-774
- https://doi.org/10.1038/356768a0
Abstract
Interleukin-1 beta (IL-1 beta)-converting enzyme cleaves the IL-1 beta precursor to mature IL-1 beta, an important mediator of inflammation. The identification of the enzyme as a unique cysteine protease and the design of potent peptide aldehyde inhibitors are described. Purification and cloning of the complementary DNA indicates that IL-1 beta-converting enzyme is composed of two nonidentical subunits that are derived from a single proenzyme, possibly by autoproteolysis. Selective inhibition of the enzyme in human blood monocytes blocks production of mature IL-1 beta, indicating that it is a potential therapeutic target.Keywords
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