Leptin therapy, insulin sensitivity, and glucose homeostasis
Open Access
- 1 January 2012
- journal article
- review article
- Published by Medknow in Indian Journal of Endocrinology and Metabolism
- Vol. 16 (9), 549-S555
- https://doi.org/10.4103/2230-8210.105571
Abstract
Glucose homeostasis is closely regulated not only by insulin, but also by leptin. Both hormones act centrally, regulating food intake and adiposity in humans. Leptin has several effects on the glucose-insulin homeostasis, some of which are independent of body weight and adiposity. Those effects of leptin are determined centrally in the hypothalamus and peripherally in the pancreas, muscles and liver. Leptin has beneficial effects on the glucose-insulin metabolism, by decreasing glycemia, insulinemia and insulin resistance. The understanding of the effects of leptin on the glucose-insulin homeostasis will lead to the development of leptin-based therapies against diabetes and other insulin resistance syndromes. In these review, we summarize the interactions between leptin and insulin, and their effects on the glucose metabolism.Keywords
This publication has 83 references indexed in Scilit:
- Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in miceJCI Insight, 2012
- Narrative Review: The Role of Leptin in Human Physiology: Emerging Clinical ApplicationsAnnals of Internal Medicine, 2010
- Regulation of Leptin Production in HumansJournal of Nutrition, 2000
- Leptin in the regulation of immunity, inflammation, and hematopoiesisJournal of Leukocyte Biology, 2000
- Functional properties of leptin receptor isoforms: internalization and degradation of leptin and ligand-induced receptor downregulation.Diabetes, 1999
- Leptin and the regulation of body weight in mammalsNature, 1998
- Identification and expression cloning of a leptin receptor, OB-RCell, 1995
- Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjectsNature Medicine, 1995
- Weight-Reducing Effects of the Plasma Protein Encoded by the obese GeneScience, 1995
- The Body-Mass Index of Twins Who Have Been Reared ApartThe New England Journal of Medicine, 1990