SAR and X-ray. A New Approach Combining Fragment-Based Screening and Rational Drug Design: Application to the Discovery of Nanomolar Inhibitors of Src SH2
- 2 May 2002
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 45 (12), 2379-2387
- https://doi.org/10.1021/jm010927p
Abstract
No abstract availableKeywords
This publication has 15 references indexed in Scilit:
- Src homology-2 domain binding assays by scintillation proximity and surface plasmon resonanceJournal of Molecular Recognition, 2001
- Peptide Ligands of pp60c-src SH2 Domains: A Thermodynamic and Structural StudyBiochemistry, 1997
- A Fluorescence Polarization Based Src-SH2 Binding AssayAnalytical Biochemistry, 1997
- Discovering High-Affinity Ligands for Proteins: SAR by NMRScience, 1996
- Automatic processing of rotation diffraction data from crystals of initially unknown symmetry and cell constantsJournal of Applied Crystallography, 1993
- Biospecific interaction analysis using biosensor technologyNature, 1993
- Requirement of pp60c-src expression for osteoclasts to form ruffled borders and resorb bone in mice.JCI Insight, 1992
- Evaluation of single-crystal X-ray diffraction data from a position-sensitive detectorJournal of Applied Crystallography, 1988
- Synthesis of new amino acids mimicking sulfated and phosphorylated tyrosine residuesThe Journal of Organic Chemistry, 1988
- Molecular charge as a determinant of macromolecule permeability across the fetal capillary endothelium of the guinea-pig placentaCell and tissue research, 1983