Mechanotransduction – a field pulling together?
- 15 October 2008
- journal article
- review article
- Published by The Company of Biologists in Journal of Cell Science
- Vol. 121 (20), 3285-3292
- https://doi.org/10.1242/jcs.023507
Abstract
Mechanical stresses are ever present in the cellular environment, whether through external forces that are applied to tissues or endogenous forces that are generated within the active cytoskeleton. Despite the wide array of studies demonstrating that such forces affect cellular signaling and function, it remains unclear whether mechanotransduction in different contexts shares common mechanisms. Here, I discuss possible mechanisms by which applied forces, cell-generated forces and changes in substrate mechanics could exert changes in cell function through common mechanotransduction machinery. I draw from examples that are primarily focused on the role of adhesions in transducing mechanical forces. Based on this discussion, emerging themes arise that connect these different areas of inquiry and suggest multiple avenues for future studies.Keywords
This publication has 99 references indexed in Scilit:
- PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motilityThe Journal of cell biology, 2008
- Retrograde Fluxes of Focal Adhesion Proteins in Response to Cell Migration and Mechanical SignalsMolecular Biology of the Cell, 2007
- The simulation of stress fibre and focal adhesion development in cells on patterned substratesJournal of The Royal Society Interface, 2007
- Magnetic microposts as an approach to apply forces to living cellsProceedings of the National Academy of Sciences of the United States of America, 2007
- Forced Unfolding of Proteins Within CellsScience, 2007
- Universal physical responses to stretch in the living cellNature, 2007
- Force Sensing by Mechanical Extension of the Src Family Kinase Substrate p130CasCell, 2006
- A bio-chemo-mechanical model for cell contractilityProceedings of the National Academy of Sciences of the United States of America, 2006
- Direct measurement of the lamellipodial protrusive force in a migrating cellThe Journal of cell biology, 2006
- An inhibitory role for FAK in regulating proliferation: a link between limited adhesion and RhoA-ROCK signalingThe Journal of cell biology, 2006