Reduced bioavailability and effect of furosemide given with food
- 1 January 1986
- journal article
- research article
- Published by Springer Science and Business Media LLC in European Journal of Clinical Pharmacology
- Vol. 29 (6), 725-727
- https://doi.org/10.1007/bf00615967
Abstract
10 healthy volunteers were given 40 mg furosemide p. o. with and without breakfast. The meal reduced the peak level of furosemide and decreased its bioavailability by approximately 30%. A heavy meal given to 5 of the subjects had no further effect. The reduced bioavailability caused a reduction in the diuretic effect.Keywords
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