Microfluidic approaches for cancer cell detection, characterization, and separation
Top Cited Papers
- 1 January 2012
- journal article
- review article
- Published by Royal Society of Chemistry (RSC) in Lab on a Chip
- Vol. 12 (10), 1753-1767
- https://doi.org/10.1039/c2lc21273k
Abstract
This article reviews the recent developments in microfluidic technologies for in vitro cancer diagnosis. We summarize the working principles and experimental results of key microfluidic platforms for cancer cell detection, characterization, and separation based on cell-affinity micro-chromatography, magnetic activated micro-sorting, and cellular biophysics (e.g., cell size and mechanical and electrical properties). We examine the advantages and limitations of each technique and discuss future research opportunities for improving device throughput and purity, and for enabling on-chip analysis of captured cancer cells.Keywords
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