Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB
- 1 August 1988
- journal article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 334 (6182), 494-498
- https://doi.org/10.1038/334494a0
Abstract
A nuclear protein, CREB, has been isolated from rat brain and shown to stimulate transcription of the cyclic AMP-responsive gene somatostatin as a dimer. Biochemical analysis suggests that dimerization and transcriptional efficacy of CREB protein in vitro are regulated by phosphorylation. These findings demonstrate that cellular signals can modulate gene expression by regulating the covalent modification of pre-existing nuclear factors.Keywords
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