Linear cyclodextrin-containing polymers and their use as delivery agents
- 1 September 2006
- journal article
- review article
- Published by Informa Healthcare in Expert Opinion on Drug Delivery
- Vol. 3 (5), 641-646
- https://doi.org/10.1517/17425247.3.5.641
Abstract
Cyclodextrins, cyclic oligomers of glucose, have been used in pharmaceutical formulations for decades as a result to their biocompatibilities, low toxicities and their abilities to solubilise organic small molecules via inclusion complex formation. The incorporation of cyclodextrins within polymers of numerous types, for use as drug delivery agents, has been explored. Illustrative of the flexibility in polymer chemistry and delivery application that is possible with these materials, two linear cyclodextrin-containing polymers are in preclinical and clinical development for the non-covalent delivery of nucleic acid therapeutics and covalent delivery of a small-molecule drug, respectively. This document provides an overview of the background and progress that has been made with these materials thus far, as well as suggestions for their future development and characterisation.Keywords
This publication has 28 references indexed in Scilit:
- Preclinical Efficacy of the Camptothecin-Polymer Conjugate IT-101 in Multiple Cancer ModelsClinical Cancer Research, 2006
- Polymer conjugates: nanosized medicines for treating cancerTrends in Biotechnology, 2006
- Pharmacokinetics and biodistribution of the camptothecin–polymer conjugate IT-101 in rats and tumor-bearing miceCancer Chemotherapy and Pharmacology, 2005
- Cyclodextrin-based pharmaceutics: past, present and futureNature Reviews Drug Discovery, 2004
- Antitumor Activity of β-Cyclodextrin Polymer−Camptothecin ConjugatesMolecular Pharmaceutics, 2004
- Synthesis of Linear, β-Cyclodextrin-Based Polymers and Their Camptothecin ConjugatesBioconjugate Chemistry, 2003
- Synthesis and in Vivo Antitumor Activity of Poly(l-glutamic acid) Conjugates of 20(S)-CamptothecinJournal of Medicinal Chemistry, 2002
- New Class of Polymers for the Delivery of Macromolecular TherapeuticsBioconjugate Chemistry, 1999
- New Organic Nanoporous Polymers and Their Inclusion ComplexesChemistry of Materials, 1999
- Molecular recognition using β-cyclodextrin-modified dendrimers: novel building blocks for convergent self-assemblyChemical Communications, 1998