Small-molecule conversion of toxic oligomers to nontoxic β-sheet–rich amyloid fibrils
- 20 November 2011
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Chemical Biology
- Vol. 8 (1), 93-101
- https://doi.org/10.1038/nchembio.719
Abstract
An orcein-related small molecule can drive polymerization of amyloid-β, implicated in Alzheimer's disease, without remodeling oligomeric or fibril forms but by stabilizing a seeding-competent protofilament state and shortening the lag phase of spontaneous polymerization.Keywords
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