Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency
Open Access
- 13 April 2020
- journal article
- research article
- Published by Elsevier BV in Journal of Biological Chemistry
- Vol. 295 (20), 6785-6797
- https://doi.org/10.1074/jbc.ra120.013679
Abstract
No abstract availableKeywords
This publication has 50 references indexed in Scilit:
- The Ambiguous Base-Pairing and High Substrate Efficiency of T-705 (Favipiravir) Ribofuranosyl 5′-Triphosphate towards Influenza A Virus PolymerasePLOS ONE, 2013
- RNA 3'-end mismatch excision by the severe acute respiratory syndrome coronavirus nonstructural protein nsp10/nsp14 exoribonuclease complexProceedings of the National Academy of Sciences of the United States of America, 2012
- In vitro and in vivo efficacy of fluorodeoxycytidine analogs against highly pathogenic avian influenza H5N1, seasonal, and pandemic H1N1 virus infectionsAntiviral Research, 2011
- Structural basis for active site closure by the poliovirus RNA-dependent RNA polymeraseProceedings of the National Academy of Sciences of the United States of America, 2010
- Ribonucleoside Triphosphates as Substrate of Human Immunodeficiency Virus Type 1 Reverse Transcriptase in Human MacrophagesJournal of Biological Chemistry, 2010
- Delayed Chain Termination Protects the Anti-hepatitis B Virus Drug Entecavir from Excision by HIV-1 Reverse TranscriptaseOnline Journal of Public Health Informatics, 2008
- MultiBac: Multigene Baculovirus‐Based Eukaryotic Protein Complex ProductionCurrent Protocols in Protein Science, 2008
- Mechanism of action of interferon and ribavirin in treatment of hepatitis CNature, 2005
- On the Role of the Crystal Environment in Determining Protein Side-chain ConformationsJournal of Molecular Biology, 2002
- Hepatitis C Virus RNA-dependent RNA Polymerase (NS5B) as a Mediator of the Antiviral Activity of RibavirinOnline Journal of Public Health Informatics, 2001