Modeling Postnatal Exposures and Their Interactions with Birth Size
Open Access
- 1 January 2004
- journal article
- research article
- Published by Elsevier BV in Journal of Nutrition
- Vol. 134 (1), 201-204
- https://doi.org/10.1093/jn/134.1.201
Abstract
The fetal origins of adult disease hypothesis postulates that the inverse association between birth weight and later adverse outcome reflects fetal programming that increases the risk of later disease. However, low birth weight is associated with catch-up after birth, and weight gain is itself a risk factor for later disease. It is difficult to disentangle the effects on outcome of the size and growth components of weight change through time. This paper presents the life course plot, a device to display both size and growth effects simultaneously. It is based on the multiple-regression analysis of the outcome on the various weights, expressed as z-scores, and the plot displays the coefficients plotted against the corresponding ages of measurement. Examples from Brazil (Pelotas) and the Phillippines (Cebu) relate blood pressure in adolescence to weight through childhood. They show small inverse weight effects in infancy, but early weight is less important than weight and weight gain during adolescence. In addition, birth length in the Cebu study affects the strength of the relationship between weight and blood pressure in adolescence. This suggests a fetal programming effect, with children who were relatively long at birth having a more sensitive relationship between blood pressure and weight at age 15. Whether this is a good or a bad thing is not immediately clear.Keywords
This publication has 10 references indexed in Scilit:
- Rapid Child Growth Raises Blood Pressure in Adolescent Boys Who Were Thin at BirthHypertension, 2003
- Low nutrient intake and early growth for later insulin resistance in adolescents born pretermThe Lancet, 2003
- Early and late growth and blood pressure in adolescenceJournal of Epidemiology and Community Health, 2003
- Unravelling the fetal origins hypothesis: is there really an inverse association between birthweight and subsequent blood pressure?The Lancet, 2002
- Infant Weight Gain and Childhood Overweight Status in a Multicenter, Cohort StudyPublished by American Academy of Pediatrics (AAP) ,2002
- Preterm birth, vascular function, and risk factors for atherosclerosisThe Lancet, 2001
- Early growth and coronary heart disease in later lifeBMJ, 2001
- Early growth and coronary heart disease in later life: longitudinal studyBMJ, 2001
- Association between postnatal catch-up growth and obesity in childhood: prospective cohort studyBMJ, 2000
- Fetal origins of adult disease---the hypothesis revisitedBMJ, 1999