NATURAL TRANSFORMATION INCREASES THE RATE OF ADAPTATION IN THE HUMAN PATHOGEN HELICOBACTER PYLORI
- 1 November 2007
- Vol. 62 (1), 39-49
- https://doi.org/10.1111/j.1558-5646.2007.00271.x
Abstract
Gene exchange between individuals can lead to profound evolutionary effects at both the genomic and population levels. These effects have sparked widespread interest in examining the specific adaptive benefits of recombination. Although this work has primarily focused on the benefits of sex in eukaryotes, it is assumed that similar benefits of genetic exchange apply across eukaryotes and prokaryotes. Here we report a direct test of this assumption using the naturally transformable human gastric pathogen Helicobacter pylori as a model organism. We show that genetic exchange accelerates adaptation to a novel laboratory environment within bacterial populations and that a general adaptive advantage exists for naturally transformable strains when transfer occurs among conspecific backgrounds. This finding demonstrates that there are generalized benefits to adaptation in both eukaryotes and prokaryotes even though the underlying processes are mechanistically different.Keywords
This publication has 38 references indexed in Scilit:
- Recombination Speeds Adaptation by Reducing Competition between Beneficial Mutations in Populations of Escherichia coliPLoS Biology, 2007
- Epistasis between deleterious mutations and the evolution of recombinationTrends in Ecology & Evolution, 2007
- Helicobacter pylori evolution and phenotypic diversification in a changing hostNature Reviews Microbiology, 2007
- Recombination and the Nature of Bacterial SpeciationScience, 2007
- Rapid Evolution of Diminished Transformability in Acinetobacter baylyiJournal of Bacteriology, 2006
- Multiple phases of competence occur during theHelicobacter pylorigrowth cycleFEMS Microbiology Letters, 2006
- Gain and Loss of Multiple Genes During the Evolution of Helicobacter pyloriPLoS Genetics, 2005
- Sex releases the speed limit on evolutionNature, 2002
- Experimental tests of the adaptive significance of sexual recombinationNature Reviews Genetics, 2002
- Long-Term Experimental Evolution in Escherichia coli. I. Adaptation and Divergence During 2,000 GenerationsThe American Naturalist, 1991