Furin: A Potential Therapeutic Target for COVID-19
Top Cited Papers
Open Access
- 5 October 2020
- journal article
- research article
- Published by Elsevier BV in iScience
- Vol. 23 (10), 101642
- https://doi.org/10.1016/j.isci.2020.101642
Abstract
No abstract availableKeywords
Funding Information
- China Postdoctoral Science Foundation
- National Natural Science Foundation of China
- Fundamental Research Funds for the Central Universities
This publication has 30 references indexed in Scilit:
- Characterization of cellular furin content as a potential factor determining the susceptibility of cultured human and animal cells to coronavirus infectious bronchitis virus infectionVirology, 2012
- ZINC: A Free Tool to Discover Chemistry for BiologyJournal of Chemical Information and Modeling, 2012
- Different host cell proteases activate the SARS-coronavirus spike-protein for cell–cell and virus–cell fusionVirology, 2011
- Evidence that TMPRSS2 Activates the Severe Acute Respiratory Syndrome Coronavirus Spike Protein for Membrane Fusion and Reduces Viral Control by the Humoral Immune ResponseJournal of Virology, 2011
- Cleavage of the SARS Coronavirus Spike Glycoprotein by Airway Proteases Enhances Virus Entry into Human Bronchial Epithelial Cells In VitroPLOS ONE, 2009
- Proteolytic Activation of the Spike Protein at a Novel RRRR/S Motif Is Implicated in Furin-Dependent Entry, Syncytium Formation, and Infectivity of Coronavirus Infectious Bronchitis Virus in Cultured CellsJournal of Virology, 2009
- Activation of the SARS coronavirus spike protein via sequential proteolytic cleavage at two distinct sitesProceedings of the National Academy of Sciences of the United States of America, 2009
- Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entryProceedings of the National Academy of Sciences of the United States of America, 2005
- The Coronavirus Spike Protein Is a Class I Virus Fusion Protein: Structural and Functional Characterization of the Fusion Core ComplexJournal of Virology, 2003
- The crystal structure of the proprotein processing proteinase furin explains its stringent specificityNature Structural & Molecular Biology, 2003