[A long-term survival case of neuroendocrine tumor of the sigmoid colon with multiple liver metastases].

Abstract

It has been reported that neuroendocrine tumor (NET) of the large intestine with distant metastasis is rare and carries poor prognosis. We report a case of colonic NET with hepatic metastases, who was successfully treated by combined therapy. A 71-year-old man with sigmoid colon tumor underwent sigmoidectomy and histopathological examination disclosed the tumor was NET grade 1. Multiple liver metastases and lymph node metastasis on the posterior surface of the pancreatic head were detected at the time of surgery. Trans-catheter arterial chemoembolization (TACE; doxorubicin and ethiodized oil and gelatine sponge particle) was performed. Partial response (PR) was observed after 2 times of administration. Radiation therapy was performed for the lymph node metastasis eight months after surgery and PR was observed. The patient was alive after 48 months and TACE was continued. Combined therapy including surgery, irradiation, and chemotherapy, although not yet standardized, is required against NET with hepatic metastases.