A Comparison of the Bronchodilating Effects of a Beta-2 Adrenergic Agent (Albuterol) and an Anticholinergic Agent (Ipratropium Bromide), Given by Aerosol Alone or in Sequence
- 18 September 1986
- journal article
- clinical trial
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 315 (12), 735-739
- https://doi.org/10.1056/nejm198609183151205
Abstract
We evaluated the effect of anticholinergic and beta-adrenergic inhaled bronchodilators, alone or in sequence, in 11 patients with chronic obstructive pulmonary disease. We compared the agents albuterol and ipratropium bromide when each was used as a single aerosol in the maximal dose. After giving a maximal dose of one agent, we compared the effect of adding the other with that of adding a placebo.Keywords
This publication has 16 references indexed in Scilit:
- Role of the Parasympathetic System in Airway Obstruction Due to EmphysemaNew England Journal of Medicine, 1984
- Comparison of Ipratropium Bromide and Salbutamol by Aerosolized SolutionAustralian and New Zealand Journal of Medicine, 1981
- Ipratropium BromideDrugs, 1980
- Ipratropium bromide, salbutamol and prednisolone in bronchial asthma and chronic bronchitisRespiratory Medicine, 1978
- A comparison of the bronchodilator activity of Sch 1000 and salbutamolJournal of Allergy and Clinical Immunology, 1977
- Comparison of aerosol ipratropium bromide and salbutamol in chronic bronchitis and asthma.BMJ, 1975
- Comparative Trial of a New Anticholinergic Bronchodilator, Sch 1000, and Salbutamol in Chronic BronchitisBMJ, 1973
- The clinical pharmacology of oral and inhaled salbutamolClinical Pharmacology & Therapeutics, 1972
- A COMPARISON BETWEEN CLINICAL, ROENTGENOLOGIC, FUNCTIONAL AND MORPHOLOGIC CRITERIA IN CHRONIC BRONCHITIS, EMPHYSEMA, ASTHMA AND BRONCHIECTASISMedicine, 1970
- A RAPID PLETHYSMOGRAPHIC METHOD FOR MEASURING THORACIC GAS VOLUME: A COMPARISON WITH A NITROGEN WASHOUT METHOD FOR MEASURING FUNCTIONAL RESIDUAL CAPACITY IN NORMAL SUBJECTS 1JCI Insight, 1956