Treatment of periungual vitiligo with Erbium‐YAG‐laser plus 5‐flurouracil: a left to right comparative study
- 20 June 2006
- journal article
- research article
- Published by Wiley in Journal of Cosmetic Dermatology
- Vol. 5 (2), 135-139
- https://doi.org/10.1111/j.1473-2165.2006.00240.x
Abstract
Despite the multiple treatment modalities available for vitiligo, none of them gives satisfactory results in the periungual type. In this study we tried to explore and evaluate the effects of the combination treatment of erbium:YAG laser resurfacing and topical 5-flurouracil in periungual vitiligo. Nine adult patients presenting with periungual vitiligo lesions were included in this prospective left-right comparative study. The desirable inflammation was achieved after a mean of 4.7 days of 5-flurouracil application. The mean re-epithelization time in the treatment sessions was 11.3 days. The patients received a mean of 3.4 sessions in a mean duration of 7.6 months. The mean overall response to therapy in the treated group was 47.8% while in the control group it was 1.1% (P < 0.0001). No side effects necessitated the stoppage of treatment. This study points to the efficacy and safety of this combination in the treatment of periungual vitiligo.Keywords
This publication has 24 references indexed in Scilit:
- What’s new in the treatment of vitiligoJournal of the European Academy of Dermatology and Venereology, 2001
- Porokeratosis of the penisBritish Journal of Dermatology, 2001
- Treatment of generalized vitiligo in children with narrow-band (TL-01) UVB radiation therapyJournal of the American Academy of Dermatology, 2000
- Repigmentation of leucodermic defects in piebaldism by dermabrasion and thin split‐thickness skin grafting in combination with minigraftingBritish Journal of Dermatology, 1998
- Treatment of vitiligo with UV-B radiation vs topical psoralen plus UV-AArchives of Dermatology, 1997
- Treatment of Vitiligo with a Topical Application of Pseudocatalase and Calcium in Combination with Short-Term UVB Exposure: A Case Study on 33 PatientsDermatology, 1995
- Repigmentation of Vitiligo Macules Treated Topically with Efudix® CreamDermatology, 1985
- Topically administered fluorouracil in vitiligoArchives of Dermatology, 1983
- Topically administered fluorouracil in psoriasisArchives of Dermatology, 1972
- The Effects of 5-Fluorouracil (5-FU) Ointment in the Treatment of Neoplastic DermatosesDermatology, 1970