Suppression of Urokinase Expression and Invasiveness by Urinary Trypsin Inhibitor Is Mediated through Inhibition of Protein Kinase C- and MEK/ERK/c-Jun-dependent Signaling Pathways
Open Access
- 1 January 2001
- journal article
- Published by Elsevier BV
- Vol. 276 (3), 2015-2022
- https://doi.org/10.1074/jbc.m007650200
Abstract
No abstract availableKeywords
This publication has 25 references indexed in Scilit:
- A bifunctional hybrid molecule of the amino‐terminal fragment of urokinase and domain II of bikunin efficiently inhibits tumor cell invasion and metastasisEuropean Journal of Biochemistry, 1998
- Identification and characterization of the cell-associated binding protein for urinary trypsin inhibitorBiochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1998
- Inhibition of metastasis of lewis lung carcinoma by urinary trypsin inhibitor in experimental and spontaneous metastasis modelsInternational Journal of Cancer, 1995
- Anti-metastatic therapy by urinary trypsin inhibitor in combination with an anti-cancer agentBritish Journal of Cancer, 1995
- Inhibitory Effect of a Conjugate between Human Urokinase and Urinary Trypsin Inhibitor on Tumor Cell Invasion in VitroPublished by Elsevier BV ,1995
- MCF-7 breast cancer cells transfected with protein kinase C-alpha exhibit altered expression of other protein kinase C isoforms and display a more aggressive neoplastic phenotype.JCI Insight, 1995
- Effects of urinary trypsin inhibitor on the invasion of reconstituted basement membranes by ovarian cancer cellsInternational Journal of Cancer, 1994
- Urinary trypsin inhibitor (UTI) and fragments derived from UTI by limited proteolysis efficiently inhibit tumor cell invasionClinical & Experimental Metastasis, 1994
- Plasminogen Activators, Tissue Degradation, and CancerAdvances in Cancer Research, 1985
- A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye bindingAnalytical Biochemistry, 1976