A study on the interactions between heparan sulfate proteoglycans and Wnt proteins
Open Access
- 24 August 2009
- journal article
- research article
- Published by Wiley in Developmental Dynamics
- Vol. 239 (1), 184-190
- https://doi.org/10.1002/dvdy.22067
Abstract
The Wnt signaling pathway plays key roles in development and adult homeostasis. Wnt proteins are secreted, lipid‐modified glycoproteins. They can form morphogen gradients that are regulated at the level of protein secretion, diffusion, and internalization. These gradients can only exist if the hydrophobic Wnt proteins are prevented from aggregating in the extracellular environment. Heparan sulfate proteoglycans (HSPGs) are necessary for proper activity of Wnt proteins and influence their distribution along the morphogenetic gradient. In this study, we show that HSPGs are able to maintain the solubility of Wnt proteins, thus stabilizing their signaling activity. Our results suggest that the role of HSPGs is not only to concentrate Wnt molecules at the cell surface but also to prevent them from aggregating in the extracellular environment. Developmental Dynamics 239:184–190, 2009.Keywords
This publication has 41 references indexed in Scilit:
- Mammalian Wnt3a is Released on Lipoprotein ParticlesTraffic, 2009
- Cellular Trafficking of the Glypican Dally-like Is Required for Full-Strength Hedgehog Signaling and Wingless TranscytosisDevelopmental Cell, 2008
- Wnt/β-catenin signaling: new (and old) players and new insightsCurrent Opinion in Cell Biology, 2008
- R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6Proceedings of the National Academy of Sciences, 2007
- Heparan Sulfate: A Complex Polymer Charged with Biological ActivityChemical Reviews, 2005
- Maternal Wnt11 Activates the Canonical Wnt Signaling Pathway Required for Axis Formation in Xenopus EmbryosCell, 2005
- Abrogation of heparan sulfate synthesis inDrosophiladisrupts the Wingless, Hedgehog and Decapentaplegic signaling pathwaysDevelopment, 2004
- QSulf1 remodels the 6-O sulfation states of cell surface heparan sulfate proteoglycans to promote Wnt signalingThe Journal of cell biology, 2003
- Zebrafish Prickle, a Modulator of Noncanonical Wnt/Fz Signaling, Regulates Gastrulation MovementsCurrent Biology, 2003
- Producing Cells Retain and Recycle Wingless in Drosophila EmbryosCurrent Biology, 2002