Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling
Open Access
- 1 September 2011
- journal article
- review article
- Published by American Society for Clinical Investigation in JCI Insight
- Vol. 121 (9), 3375-3383
- https://doi.org/10.1172/jci57158
Abstract
The successful treatment of certain autoimmune conditions with the humanized anti–IL-6 receptor (IL-6R) antibody tocilizumab has emphasized the clinical importance of cytokines that signal through the β-receptor subunit glycoprotein 130 (gp130). In this Review, we explore how gp130 signaling controls disease progression and examine why IL-6 has a special role among these cytokines as an inflammatory regulator. Attention will be given to the role of the soluble IL-6R, and we will provide a perspective into the clinical blockade of IL-6 activity in autoimmunity, inflammation, and cancer.Keywords
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