Theionbrunonines A and B: Dimeric Vobasine Alkaloids Tethered by a Thioether Bridge from Mostuea brunonis
- 19 October 2018
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 20 (20), 6596-6600
- https://doi.org/10.1021/acs.orglett.8b02961
Abstract
Theionbrunonines A and B (1 and 2), the first examples of monoterpene bisindole alkaloids linked by a thioether bridge, were isolated from the stems of Mostuea brunonis, guided by a molecular networking-based dereplication strategy. Their structures were elucidated by a combination of spectroscopic data and ECD calculations. A plausible biosynthetic pathway for 1 and 2 was postulated. Theionbrunonines A and B (1 and 2) showed moderate antiplasmodial activities in the micromolar range against the strain FcB1 of Plasmodium falciparum and no cytotoxic activity against the MRC-5 cell line at 20 mu M.Funding Information
- Agence Nationale de la Recherche (ANR-15-CE29-0001)
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