Hip Fracture and the Use of Estrogens in Postmenopausal Women
- 5 November 1987
- journal article
- Published by Massachusetts Medical Society in The New England Journal of Medicine
- Vol. 317 (19), 1169-1174
- https://doi.org/10.1056/nejm198711053171901
Abstract
To assess the effect of postmenopausal use of estrogens on the subsequent risk of hip fracture, we performed a retrospective cohort study of 2873 women in the Framingham Heart Study. Information obtained at routine biennial examinations about the use of estrogens, body weight, age at menopause, smoking, and alcohol consumption was used to evaluate the risk of hip fracture among postmenopausal women who received estrogens. Hip fractures occurred in 179 postmenopausal women, at a rate that increased exponentially after the age of 50. The risk of fracture was inversely related to weight at all ages. The relative risk of hip fracture in subjects who had taken estrogens at any time was 0.65 after adjustment for age and weight (95 percent confidence interval, 0.44 to 0.98). The adjusted relative risk in women who had taken estrogens within the previous two years was further reduced, to 0.34 (95 percent confidence interval, 0.12 to 0.98). Taking estrogens within four years of menopause also protected against fracture. The number of women in each age group who took estrogens was insufficient for a definitive evaluation of risk, but recent use of estrogens appeared to be protective in women under the age of 65 (no fractures among those who took estrogens) and those 65 to 74.Keywords
This publication has 36 references indexed in Scilit:
- The decline of grip strength in the menopause: Relationship to physical activity, estrogen use and anthropometric factorsJournal of Chronic Diseases, 1987
- Does Calcium Supplementation Prevent Postmenopausal Bone Loss?The New England Journal of Medicine, 1987
- The Effect of Estrogen Dose on Postmenopausal Bone LossThe New England Journal of Medicine, 1983
- TREATMENT OF POST MENOPAUSAL OSTEOPOROSIS. A CONTROLLED THERAPEUTIC TRIAL COMPARING OESTROGEN/GESTAGEN, 1,25-DIHYDROXY-VITAMIN D3AND CALCIUMClinical Endocrinology, 1982
- On Aging Bone LossClinical Orthopaedics and Related Research, 1982
- Effect of the Fluoride/Calcium Regimen on Vertebral Fracture Occurrence in Postmenopausal OsteoporosisThe New England Journal of Medicine, 1982
- BONE MASS IN POSTMENOPAUSAL WOMEN AFTER WITHDRAWAL OF OESTROGEN/GESTAGEN REPLACEMENT THERAPYThe Lancet, 1981
- Decreased Risk of Fractures of the Hip and Lower Forearm with Postmenopausal Use of EstrogenThe New England Journal of Medicine, 1980
- Endometrial Cancer and Estrogen UseThe New England Journal of Medicine, 1979
- BONE RESPONSE TO TERMINATION OF ŒSTROGEN TREATMENTThe Lancet, 1978