The penetration of metronidazole into synovial fluid
Open Access
- 1 January 1982
- journal article
- research article
- Published by Oxford University Press (OUP) in Heart
- Vol. 58 (675), 20-24
- https://doi.org/10.1136/pgmj.58.675.20
Abstract
Six patients with non-infected synovial effusions, associated either with inflammatory or degenerative arthropathy and requiring diagnostic or therapeutic aspiration, were given a short course of 400 mg metronidazole (Flagyl) 8-hourly for 3 doses. Serum and synovial fluid (SF) were sampled frequently during this time, and assayed for metronidazole by a specific high pressure liquid-chromatographic method. It was found that concentrations of metronidazole in SF reached those in serum after a short time-lag, and thereafter approximated to the serum concentration. With this regimen, metronidazole concentrations were readily achieved in synovial fluid, above the minimum inhibitory concentrations for most susceptible anaerobes. These results indicate that the drug freely enters the synovial fluid and suggests that metronidazole would prove effective in the treatment of septic arthritis due to anaerobic bacteria.Keywords
This publication has 31 references indexed in Scilit:
- Pharmacokinetics of Metronidazole in Pregnant WomenChemotherapy, 1981
- Pharmacokinetics of Metronidazole in Healthy Adult Volunteers after Tablets and SuppositoriesChemotherapy, 1980
- The pharmacokinetics of oral and intravenous metronidazole in manJournal of Antimicrobial Chemotherapy, 1979
- Metronidazole in Anaerobic InfectionsDrugs, 1978
- The penetration of antibiotics into cerebrospinal fluid and brain tissueJournal of Antimicrobial Chemotherapy, 1978
- BACTEROIDACEAE BACTEREMIAMedicine, 1974
- CLINDAMYCIN AND PSEUDOMEMBRANOUS COLITISThe Lancet, 1974
- ANAEROBIC PLEUROPULMONARY INFECTIONSMedicine, 1972
- Joint infection by anaerobic bacteria: A case report and review of the literatureArthritis & Rheumatism, 1969
- Suppurative Arthritis Complicating Rheumatoid ArthritisBMJ, 1958