Assessing the risk of Nipah virus establishment in Australian flying-foxes
Open Access
- 4 February 2014
- journal article
- viral infections
- Published by Cambridge University Press (CUP) in Epidemiology and Infection
- Vol. 143 (10), 2213-2226
- https://doi.org/10.1017/s0950268813003336
Abstract
SUMMARY: Nipah virus (NiV) is a recently emerged zoonotic virus that causes severe disease in humans. The reservoir hosts for NiV, bats of the genusPteropus(known as flying-foxes) are found across the Asia-Pacific including Australia. While NiV has not been detected in Australia, evidence for NiV infection has been found in flying-foxes in some of Australia's closest neighbours. A qualitative risk assessment was undertaken to assess the risk of NiV establishing in Australian flying-foxes through flying-fox movements from nearby regions. Events surrounding the emergence of new diseases are typically uncertain and in this study an expert opinion workshop was used to address gaps in knowledge. Given the difficulties in combining expert opinion, five different combination methods were analysed to assess their influence on the risk outcome. Under the baseline scenario where the median was used to combine opinions, the risk was estimated to be very low. However, this risk increased when the mean and linear opinion pooling combination methods were used. This assessment highlights the effects that different methods for combining expert opinion have on final risk estimates and the caution needed when interpreting these outcomes given the high degree of uncertainty in expert opinion. This work has provided a flexible model framework for assessing the risk of NiV establishment in Australian flying-foxes through bat movements which can be updated when new data become available.Keywords
This publication has 56 references indexed in Scilit:
- The Distribution of Henipaviruses in Southeast Asia and Australasia: Is Wallace’s Line a Barrier to Nipah Virus?PLOS ONE, 2013
- Biochemical, Conformational, and Immunogenic Analysis of Soluble Trimeric Forms of Henipavirus Fusion GlycoproteinsJournal of Virology, 2012
- Evidence of Endemic Hendra Virus Infection in Flying-Foxes (Pteropus conspicillatus)—Implications for Disease Risk ManagementPLOS ONE, 2011
- Identifying Hendra Virus Diversity in Pteropid BatsPLOS ONE, 2011
- Induction of neutralizing antibodies to Hendra and Nipah glycoproteins using a Venezuelan equine encephalitis virus in vivo expression systemVaccine, 2010
- The use of expert elicitation in environmental health impact assessment: a seven step procedureEnvironmental Health, 2010
- Evidence of Henipavirus Infection in West African Fruit BatsPLOS ONE, 2008
- Henipavirus susceptibility to environmental variablesVirus Research, 2008
- Reproduction and nutritional stress are risk factors for Hendra virus infection in little red flying foxes ( Pteropus scapulatus )Proceedings. Biological sciences, 2008
- Bats: Important Reservoir Hosts of Emerging VirusesClinical Microbiology Reviews, 2006