Heart Rate and Risk of Cancer Death in Healthy Men
Open Access
- 3 August 2011
- journal article
- research article
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 6 (8), e21310
- https://doi.org/10.1371/journal.pone.0021310
Abstract
Data from several previous studies examining heart-rate and cardiovascular risk have hinted at a possible relationship between heart-rate and non-cardiac mortality. We thus systematically examined the predictive value of heart-rate variables on the subsequent risk of death from cancer. In the Paris Prospective Study I, 6101 asymptomatic French working men aged 42 to 53 years, free of clinically detectable cardiovascular disease and cancer, underwent a standardized graded exercise test between 1967 and 1972. Resting heart-rate, heart-rate increase during exercise, and decrease during recovery were measured. Change in resting heart-rate over 5 years was also available in 5139 men. Mortality including 758 cancer deaths was assessed over the 25 years of follow-up. There were strong, graded and significant relationships between all heart-rate parameters and subsequent cancer deaths. After adjustment for age and tobacco consumption and, compared with the lowest quartile, those with the highest quartile for resting heart-rate had a relative risk of 2.4 for cancer deaths (95% confidence interval: 1.9–2.9, p<0.0001) This was similar after adjustment for traditional cardiovascular risk factors and was observed for the commonest malignancies (respiratory and gastrointestinal). Similarly, significant relationships with cancer death were observed between poor heart rate increase during exercise, poor decrease during recovery and greater heart-rate increase over time (p<0.0001 for all). Resting and exercise heart rate had consistent, graded and highly significant associations with subsequent cancer mortality in men.Keywords
This publication has 31 references indexed in Scilit:
- Relation of Heart Rate at Rest and Long-Term (>20 Years) Death Rate in Initially Healthy Middle-Aged MenThe American Journal of Cardiology, 2009
- Prognostic Value of Heart Rate Increase at Onset of Exercise TestingCirculation, 2007
- Impact of Increased Heart Rate on Clinical Outcomes in HypertensionDrugs, 2006
- Rapid Heart Rate Increase at Onset of Exercise Predicts Adverse Cardiac Events in Patients With Coronary Artery DiseaseCirculation, 2005
- Heart-Rate Profile during Exercise as a Predictor of Sudden DeathThe New England Journal of Medicine, 2005
- Overweight, Obesity, and Mortality from Cancer in a Prospectively Studied Cohort of U.S. AdultsThe New England Journal of Medicine, 2003
- The association of resting heart rate with cardiovascular, cancer and all-cause mortality. Eight year follow-up of 3527 male Israeli employees (the CORDIS Study)European Heart Journal, 2000
- Heart-Rate Recovery Immediately after Exercise as a Predictor of MortalityThe New England Journal of Medicine, 1999
- Influence of Heart Rate on Mortality in a French PopulationHypertension, 1999
- Heart rate and cardiovascular mortality: The Framingham studyAmerican Heart Journal, 1987