Verbal learning and memory in patients with dementia with Lewy bodies or Parkinson's disease with dementia
Open Access
- 10 September 2009
- journal article
- research article
- Published by Taylor & Francis Ltd in Journal of Clinical and Experimental Neuropsychology
- Vol. 31 (7), 823-834
- https://doi.org/10.1080/13803390802572401
Abstract
This study compared verbal learning and memory in patients with autopsy-confirmed dementia with Lewy bodies (DLB) and patients with Parkinson's disease with dementia (PDD). A total of 24 DLB patients, 24 PDD patients, and 24 normal comparison participants were administered the California Verbal Learning Test. The three groups were matched on demographic variables, and the two patient groups were matched on the Mattis Dementia Rating Scale. The results indicated that DLB patients recalled less information than PDD patients on all but one recall measure and displayed a more rapid rate of forgetting. In contrast, the PDD patients committed a greater percentage of perseveration errors than the DLB patients. The two groups did not differ in the percentage of recall intrusion errors or any measures of recognition. A discriminant function analysis (DFA) using short-delay cued recall, percentage of perseveration errors, and List B recall differentiated the DLB and PDD groups with 81.3% accuracy. The application of the DFA algorithm to another sample of 42 PDD patients resulted in a 78.6% correct classification rate. The results suggest that, despite equivalent levels of general cognitive impairment, patients with DLB or PDD exhibit a different pattern of verbal learning and memory deficits.Keywords
This publication has 44 references indexed in Scilit:
- A comparison of episodic memory deficits in neuropathologically-confirmed Dementia with Lewy bodies and Alzheimer's diseaseJournal of the International Neuropsychological Society, 2004
- Are Parkinson’s Disease with dementia and Dementia with lewy Bodies the Same Entity?Journal of Geriatric Psychiatry and Neurology, 2004
- Comparison of dementia with Lewy bodies to Alzheimer's disease and Parkinson's disease with dementiaMovement Disorders, 2004
- Discrimination of Dementia With Lewy Bodies From Alzheimer Disease and Parkinson Disease Using the Clock Drawing TestCognitive and Behavioral Neurology, 2003
- Variable memory profiles in parkinson's diseaseJournal of Clinical and Experimental Neuropsychology, 1997
- Motor and cognitive function in Lewy body dementia: comparison with Alzheimer's and Parkinson's diseases.Journal of Neurology, Neurosurgery & Psychiatry, 1997
- Regional Brain Atrophy in Idiopathic Parkinson's Disease and Diffuse Lewy Body DiseaseDementia and Geriatric Cognitive Disorders, 1996
- Neuropathological stageing of Alzheimer-related changesActa Neuropathologica, 1991
- Are all subcortical dementias Alike?: Verbal learning and memory in Parkinson's and huntington's disease patientsJournal of Clinical and Experimental Neuropsychology, 1990
- ParkinsonismNeurology, 1967