Pd(II)-Catalyzed Carbonylation of C(sp3)−H Bonds: A New Entry to 1,4-Dicarbonyl Compounds
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- 17 November 2010
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 132 (49), 17378-17380
- https://doi.org/10.1021/ja108754f
Abstract
Pd(II)-catalyzed β-C(sp3)−H carbonylation of N-arylamides under CO (1 atm) has been achieved. Following amide-directed C(sp3)−H cleavage and insertion of CO into the resulting [Pd(II)−C(sp3)] bond, intramolecular C−N reductive elimination gave the corresponding succinimides, which could be readily converted to 1,4-dicarbonyl compounds. This method was found to be effective with substrates containing α-hydrogen atoms and could be applied to effect methylene C(sp3)−H carbonylation of cyclopropanes.This publication has 40 references indexed in Scilit:
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