The complement system
- 14 September 2010
- journal article
- review article
- Published by Springer Science and Business Media LLC in Cell and tissue research
- Vol. 343 (1), 227-235
- https://doi.org/10.1007/s00441-010-1034-0
Abstract
The complement system consists of a tightly regulated network of proteins that play an important role in host defense and inflammation. Complement activation results in opsonization of pathogens and their removal by phagocytes, as well as cell lysis. Inappropriate complement activation and complement deficiencies are the underlying cause of the pathophysiology of many diseases such as systemic lupus erythematosus and asthma. This review represents an overview of the complement system in an effort to understand the beneficial as well as harmful roles it plays during inflammatory responses.Keywords
This publication has 62 references indexed in Scilit:
- Mechanisms involved in antibody- and complement-mediated allograft rejectionImmunologic Research, 2010
- Recent developments in low molecular weight complement inhibitorsMolecular Immunology, 2009
- The role of the anaphylatoxins in health and diseaseMolecular Immunology, 2009
- The human complement fragment receptor, C5L2, is a recycling decoy receptorMolecular Immunology, 2009
- Complement activation and inhibition: a delicate balanceTrends in Immunology, 2009
- Sepsis, apoptosis and complementBiochemical Pharmacology, 2008
- Biological activities of C1 inhibitorMolecular Immunology, 2008
- Locally Produced Complement Fragments C5a and C3a Provide Both Costimulatory and Survival Signals to Naive CD4+ T CellsImmunity, 2008
- Complement-targeted therapeuticsNature Biotechnology, 2007
- Interactions between mannose-binding lectin and MASPs during complement activation by the lectin pathwayImmunobiology, 2007