Innate lymphoid cells — how did we miss them?
- 7 January 2013
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Reviews Immunology
- Vol. 13 (2), 75-87
- https://doi.org/10.1038/nri3349
Abstract
Innate lymphoid cells (ILCs) are newly identified members of the lymphoid lineage that have emerging roles in mediating immune responses and in regulating tissue homeostasis and inflammation. Here, we review the developmental relationships between the various ILC lineages that have been identified to date and summarize their functions in protective immunity to infection and their pathological roles in allergic and autoimmune diseases.Keywords
This publication has 108 references indexed in Scilit:
- The Transcription Factor GATA-3 Controls Cell Fate and Maintenance of Type 2 Innate Lymphoid CellsImmunity, 2012
- The Transcription Factor T-bet Regulates Intestinal Inflammation Mediated by Interleukin-7 Receptor+ Innate Lymphoid CellsImmunity, 2012
- Epithelial Cell-Specific Act1 Adaptor Mediates Interleukin-25-Dependent Helminth Expulsion through Expansion of Lin−c-Kit+ Innate Cell PopulationImmunity, 2012
- The Aryl Hydrocarbon Receptor Regulates Gut Immunity through Modulation of Innate Lymphoid CellsImmunity, 2011
- Innate lymphoid cells responding to IL-33 mediate airway hyperreactivity independently of adaptive immunityJournal of Allergy and Clinical Immunology, 2011
- Id2 expression delineates differential checkpoints in the genetic program of CD8α+and CD103+dendritic cell lineagesThe EMBO Journal, 2011
- CD4+ Lymphoid Tissue-Inducer Cells Promote Innate Immunity in the GutImmunity, 2010
- Regulated Expression of Nuclear Receptor RORγt Confers Distinct Functional Fates to NK Cell Receptor-Expressing RORγt+ Innate LymphocytesImmunity, 2010
- Nuocytes represent a new innate effector leukocyte that mediates type-2 immunityNature, 2010
- T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγImmunity, 2008